Tumor lysate-loaded biodegradable microparticles as cancer vaccines

Tumor lysate-loaded biodegradable microparticles as cancer vaccines.

Cancer vaccines that use tumor lysate (TL) as a source of tumor-associated antigens (TAAs) have significant potential for generating therapeutic anti-tumor immune responses. Vaccines encompassing TL bypass the limitations of single antigen vaccines by simultaneously stimulating immunity against multiple TAAs, thereby broadening the repertoire of TAA-specific T-cell clones available for activati...

encapsulation of gastric tumor lysate in plga nanoparticles as antigen delivery system for anti-tumor vaccines

Biodegradable microparticles for in situ immunization against cancer

Recommended Citation Makkouk, Amani Riad. "Biodegradable microparticles for in situ immunization against cancer." PhD (Doctor of Philosophy) thesis, ii To my daughter Nairmeen Fariha, who is the light of my days iii ACKNOWLEDGMENTS First and foremost I would like to thank my advisor George Weiner. I truly appreciate all his contributions of time and critical thinking to make my PhD experience p...

Synthesis of Biodegradable Hydrogel Microparticles

Soluble protein antigens used in vaccines have shown lower immune responses when compared with certain particulate forms of these same antigens. For example, it has been shown that microand nano-particle mediated delivery of protein antigen can use up to 100 times less protein and still produce an effective immune response [1]. In order to use this phenomenon to make vaccines more efficient, we...

Rapid production of protein-loaded biodegradable microparticles using surface acoustic waves.

We present a straightforward and rapid surface acoustic wave (SAW) atomization-based technique for encapsulating proteins into 10 mum order particles composed of a biodegradable polymeric excipient, using bovine serum albumin (BSA) as an exemplar. Scans obtained from confocal microscopy provide qualitative proof of encapsulation and show the fluorescent conjugated protein to be distributed in a...